Reigan, P.: search on Z-Library

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1

Strategies and approaches of targeting STAT3 for cancer treatment

Furtek, Steffanie L, Backos, Donald S., Matheson, Christopher J, Reigan, Philip

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

2

Structure-based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors

Xiong, W., Matheson, C. J., Xu, M., Backos, D. S., Mills, T. S., Salian-Mehta, S., Kiseljak-Vassiliades, K., Reigan, P., Wierman, M. E.

Journal:

Molecular Cancer Therapeutics

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

3

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors

Matheson, Christopher J., Casalvieri, Kimberly A., Backos, Donald S., Minhajuddin, Mohammed, Jordan, Craig T., Reigan, Philip

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.56 MB

2020

4

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors

Philip Reigan, Abdul Gbaj, Ian J. Stratford, Richard A. Bryce, Sally Freeman

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 825 KB

english, 2008

5

Indolequinone Inhibitors of NRH:Quinone Oxidoreductase 2. Characterization of the Mechanism of Inhibition in both Cell-Free and Cellular Systems

Yan, Chao, Dufour, Marine, Siegel, David, Reigan, Philip, Gomez, Joe, Shieh, Biehuoy, Moody, Christopher J., Ross, David

Journal:

Year:

2011

Language:

english

File:

PDF, 3.11 MB

english, 2011

6

Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition

Marine Dufour, Chao Yan, Dr. David Siegel, Dr. Marie A. Colucci, Matthew Jenner, Dr. Neil J. Oldham, Joe Gomez, Dr. Philip Reigan, Yazhuo Li, Dr. Cristina I. De Matteis, Prof. Dr. David Ross, Prof. Dr

Journal:

Year:

2011

Language:

english

File:

PDF, 397 KB

english, 2011

7

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4

Gates, Christina, Backos, Donald S., Reigan, Philip, Kang, Hye Jin, Koerner, Chris, Mirzaei, Joseph, Natale, N.R.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.84 MB

english, 2018

8

Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action

Guo, W., Reigan, P., Siegel, D., Ross, D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 381 KB

english, 2008

9

Molecular docking of substituted pteridinones and pyrimidines to the ATP-binding site of the N-terminal domain of RSK2 and associated MM/GBSA and molecular field datasets

Casalvieri, Kimberly A., Matheson, Christopher J., Backos, Donald S., Reigan, Philip

Journal:

Year:

2020

Language:

english

File:

PDF, 3.63 MB

english, 2020

10

Interleukin-6/STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma

Griesinger, A. M., Josephson, R. J., Donson, A. M., Mulcahy Levy, J. M., Amani, V., Birks, D. K., Hoffman, L. M., Furtek, S. L., Reigan, P., Handler, M. H., Vibhakar, R., Foreman, N. K.

Journal:

Cancer Immunology Research

Year:

2015

Language:

english

File:

PDF, 901 KB

english, 2015

11

4-HNE Significantly Alters L-FABP Structural and Functional Dynamics

Rebecca L Smathers, Philip Reigan, Kristofer S Fritz, James J Galligan, Colin T Shearn, Dennis R Petersen

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 59 KB

english, 2011

12

Development of potent pyrazolopyrimidinone-based WEE1 inhibitors with limited single-agent cytotoxicity for cancer therapy

Matheson, Christopher J, Casalvieri, Kimberly A, Backos, Donald S, Reigan, Philip

Journal:

Year:

2018

Language:

english

File:

PDF, 5.91 MB

english, 2018

13

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors

Furtek, Steffanie L., Matheson, Christopher J., Backos, Donald S., Reigan, Philip

Journal:

Year:

2016

Language:

english

File:

PDF, 4.32 MB

english, 2016

14

Determinants of adipophilin function in milk lipid formation and secretion

Brandi M. Chong, Philip Reigan, Kasey D. Mayle-Combs, David J. Orlicky, James L. McManaman

Journal:

Trends in Endocrinology & Metabolism

Year:

2011

Language:

english

File:

PDF, 460 KB

english, 2011

15

Enzyme Specific Activation of Benzoquinone Ansamycin Prodrugs Using HuCC49ΔCH2−β-Galactosidase Conjugates

Fang, Lanyan, Battisti, Robert F., Cheng, Hao, Reigan, Philip, Xin, Yan, Shen, Jie, Ross, David, Chan, Kenneth K., Martin, Edward W., Wang, Peng George, Sun, Duxin

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 593 KB

english, 2006

16

Targeting WEE1 Kinase in Cancer

Matheson, Christopher J., Backos, Donald S., Reigan, Philip

Journal:

Trends in Pharmacological Sciences

Year:

2016

Language:

english

File:

PDF, 1.82 MB

english, 2016

17

Selective Targeting of RSK Isoforms in Cancer

Casalvieri, Kimberly A., Matheson, Christopher J., Backos, Donald S., Reigan, Philip

Journal:

Trends in Cancer

Year:

2017

Language:

english

File:

PDF, 1.67 MB

english, 2017

18

Potential Tumor-Selective Nitroimidazolylmethyluracil Prodrug Derivatives: Inhibitors of the Angiogenic Enzyme Thymidine Phosphorylase

Cole, Christian, Reigan, Philip, Gbaj, Abdul, Edwards, Philip N., Douglas, Kenneth T., Stratford, Ian J., Freeman, Sally, Jaffar, Mohammed

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

19

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein–protein interactions with HPRT1

Vasiliou, Vasilis, Sandoval, Monica, Backos, Donald S., Jackson, Brian C., Chen, Ying, Reigan, Philip, Lanaspa, Miguel A., Johnson, Richard J., Koppaka, Vindhya, Thompson, David C.

Journal:

Chemico-Biological Interactions

Year:

2013

Language:

english

File:

PDF, 2.00 MB

english, 2013

20

The Adipophilin C Terminus Is a Self-folding Membrane-binding Domain That Is Important for Milk Lipid Secretion

Chong, B. M., Russell, T. D., Schaack, J., Orlicky, D. J., Reigan, P., Ladinsky, M., McManaman, J. L.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 3.73 MB

english, 2011

21

Aminoimidazolylmethyluracil Analogues as Potent Inhibitors of Thymidine Phosphorylase and Their Bioreductive Nitroimidazolyl Prodrugs

Reigan, Philip, Edwards, Philip N., Gbaj, Abdul, Cole, Christian, Barry, Simon T., Page, Ken M., Ashton, Susan E., Luke, Richard W. A., Douglas, Kenneth T., Stratford, Ian J.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 307 KB

english, 2005

22

4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

Fritz, Kristofer S., Galligan, James J., Smathers, Rebecca L., Roede, James R., Shearn, Colin T., Reigan, Philip, Petersen, Dennis R.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 5.78 MB

english, 2011

23

Genetic Variants of Lipoprotein Lipase and Regulatory Factors Associated with Alzheimerâs Disease Risk

D. Bruce, Kimberley, Tang, Maoping, Reigan, Philip, H. Eckel, Robert

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 877 KB

2020

24

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis

Ryan, K., Backos, D. S., Reigan, P., Patel, M.

Journal:

Journal of Neuroscience

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

25

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Balakrishnan, Ilango, Cristiano, Brian, Donson, Andrew M, Dubuc, Adrian M, Taylor, Michael D, Foreman, Nicholas K, Reigan, Phili

Journal:

Molecular Cancer

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

26

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

Shearn, C. T., Fritz, K. S., Reigan, P., Petersen, Dennis R.

Journal:

Year:

2011

Language:

english

File:

PDF, 3.19 MB

english, 2011

27

Reactive Aldehyde 4-Hydroxynonenal Inhibits Mitochondrial Sirt3 Deacetylase Activity

Kristofer S Fritz, James J Galligan, Rebecca L Smathers, James R Roede, Colin T Shearn, Philip Reigan, Dennis R Petersen

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 388 KB

english, 2010

28

Synthesis and Evaluation of 3-Aryloxymethyl-1,2-dimethylindole-4,7-diones as Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Activity

Colucci, Marie A., Reigan, Philip, Siegel, David, Chilloux, Aurélie, Ross, David, Moody, Christopher J.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 144 KB

english, 2007

29

In Vitro and in Silico Characterization of Peroxiredoxin 6 Modified by 4-Hydroxynonenal and 4-Oxononenal

Roede, James R., Carbone, David L., Doorn, Jonathan A., Kirichenko, Oleg V., Reigan, Philip, Petersen, Dennis R.

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 12.01 MB

english, 2008

30

RSK3: A regulator of pathological cardiac remodeling

Martinez, Eliana C., Passariello, Catherine L., Li, Jinliang, Matheson, Christopher J., Dodge-Kafka, Kimberly, Reigan, Philip, Kapiloff, Michael S.

Journal:

Year:

2015

Language:

english

File:

PDF, 452 KB

english, 2015

31

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: a structure-activity study

Casalvieri, Kimberly A., Matheson, Christopher J., Backos, Donald S., Reigan, Philip

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 1.74 MB

2020

32

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase

Philip Reigan, Abdul Gbaj, Edwin Chinje, Ian J. Stratford, Kenneth T. Douglas, Sally Freeman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 281 KB

english, 2004

33

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2

Jackson, Brian C., Holmes, Roger S., Backos, Donald S., Reigan, Philip, Thompson, David C., Vasiliou, Vasilis

Journal:

Chemico-Biological Interactions

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

34

Inhibition of Wee1 Sensitizes Cancer Cells to Antimetabolite Chemotherapeutics In Vitro and In Vivo, Independent of p53 Functionality

Van Linden, A. A., Baturin, D., Ford, J. B., Fosmire, S. P., Gardner, L., Korch, C., Reigan, P., Porter, C. C.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1001 KB

english, 2013

35

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells

Matheson, Christopher J., Venkataraman, Sujatha, Amani, Vladimir, Harris, Peter S., Backos, Donald S., Donson, Andrew M., Wempe, Michael F., Foreman, Nicholas K., Vibhakar, Rajeev, Reigan, Philip

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 776 KB

english, 2016

36

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter

Steiger, Scott A., Li, Chun, Backos, Donald S., Reigan, Philip, Natale, N.R.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.76 MB

english, 2017

37

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

Shearn, C.T., Smathers, R.L., Backos, D.S., Reigan, P., Orlicky, D.J., Petersen, Dennis R.

Journal:

Free Radical Biology and Medicine

Year:

2013

Language:

english

File:

PDF, 10.20 MB

english, 2013

38

Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-transretinaldehyde—In VitroStudies and Computational Modeling

Jackson, Brian C., Reigan, Philip, Miller, Bettina, Thompson, David C., Vasiliou, Vasilis

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 2.09 MB

english, 2015

39

Manganese Superoxide Dismutase Regulates a Metabolic Switch during the Mammalian Cell Cycle

Sarsour, E. H., Kalen, A. L., Xiao, Z., Veenstra, T. D., Chaudhuri, L., Venkataraman, S., Reigan, P., Buettner, G. R., Goswami, P. C.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

40

The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins

Guo, W., Reigan, P., Siegel, D., Zirrolli, J., Gustafson, D., Ross, D.

Journal:

Molecular Pharmacology

Year:

2006

Language:

english

File:

PDF, 715 KB

english, 2006

41

Acrolein Inhibits Cytokine Gene Expression by Alkylating Cysteine and Arginine Residues in the NF- B1 DNA Binding Domain

Lambert, C., Li, J., Jonscher, K., Yang, T.-C., Reigan, P., Quintana, M., Harvey, J., Freed, B. M.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.55 MB

english, 2007

42

10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties

Weaver, Matthew J., Stump, Sascha, Campbell, Michael J., Backos, Donald S., Li, Chun, Reigan, Philip, Adams, Earle, Beall, Howard D., Natale, Nicholas R.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 3.44 MB

2020

43

Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells

Colin T. Shearn, Philip Reigan, Dennis R. Petersen

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 1.54 MB

english, 2012

44

AIMing towards improved antitumor efficacy

Weaver, Matthew J., Kearns, Alison K., Stump, Sascha, Li, Chun, Gajewski, Mariusz P., Rider, Kevin C., Backos, Donald S., Reigan, Philip R., Beall, Howard D., Natale, Nicholas R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

45

Development of Indolequinone Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1): NQO1 Inhibition and Growth Inhibitory Activity in Human Pancreatic MIA PaCa-2 Cancer Cells †

Reigan, Philip, Colucci, Marie A., Siegel, David, Chilloux, Aurélie, Moody, Christopher J., Ross, David

Journal:

Year:

2007

Language:

english

File:

PDF, 979 KB

english, 2007

46

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells

Matheson, Christopher J., Venkataraman, Sujatha, Amani, Vladimir, Harris, Peter S., Backos, Donald S., Donson, Andrew M., Wempe, Michael F., Foreman, Nicholas K., Vibhakar, Rajeev, Reigan, Philip

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.90 MB

english, 2016

47

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

Ponder, Jessica, Yoo, Byong Hoon, Abraham, Adedoyin D., Li, Qun, Ashley, Amanda K., Amerin, Courtney L., Zhou, Qiong, Reid, Brian G., Reigan, Philip, Hromas, Robert, Nickoloff, Jac A., LaBarbera, Dani

Journal:

Year:

2011

Language:

english

File:

PDF, 904 KB

english, 2011

48

Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinsonâs disease

Anderson, Colin C., Marentette, John O., Rauniyar, Abhishek K., Prutton, Kendra, Khatri, Meera, Matheson, Chris, Reisz, Julie A., Reigan, Philip, DâAlessandro, Angelo, Roede, James R.

Journal:

Free Radical Biology and Medicine

Year:

2020

File:

PDF, 4.90 MB

2020

49

The role of glutathione in brain tumor drug resistance

Donald S. Backos, Christopher C. Franklin, Philip Reigan

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 525 KB

english, 2012

50

Carbonylation and Inhibition of Mitochondrial Complex I during Kainate-Induced Epileptogenesis

Kristen R. Ryan, Li-Ping Liang, Donald S. Backos, Philip Reigan, Manisha Patel

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 54 KB

english, 2011

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